CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34 stem/progenitor cells to the bone marrow Short title: CD44 AND HYALURONIC ACID IN HUMAN HPC TRAFFICKING Scientific section heading: HEMATOPOIESIS
نویسندگان
چکیده
Immunology Department, Weizmann Institute of Science, Rehovot, 76100, Israel; Hematology and Bone Marrow Transplantation Department, Chaim Sheba Medical Center, Tel-Hashomer, Israel; Gene Therapy Institute, Hadassah University Hospital, Jerusalem, Israel; Department of Internal Medicine, Assaf-Harofeh Medical Center, Zerifin, Israel; Laboratory of Experimental Medicine, Park Rabin, Rehovot, Israel; The Lautenberg Center for General and Tumor Immunology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
منابع مشابه
CD44 and hyaluronic acid cooperate with SDF-1 in the trafficking of human CD34+ stem/progenitor cells to bone marrow.
Trafficking of human CD34+ stem/progenitor cells (HSCs/HPCs) is regulated by chemokines, cytokines, proteolytic enzymes, and adhesion molecules. We report that the adhesion receptor CD44 and its major ligand, hyaluronic acid (HA), are essential for homing into the bone marrow (BM) and spleen of nonobese diabetic/severe combined immunodeficient (NOD/SCID) mice and engraftment by human HSCs. Homi...
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